HRAS

Across TCGA patient cohorts, HRAS RNA expression is significantly associated with the protein abundance of many other proteins, with 11,913 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HRAS-associated proteins across cancer lineages are RRM1, TXNDC5, and SPCS3. Each is linked with HRAS in more than 6 cancer types. Because this analysis shows association rather than direction, both HRAS-to-partner and partner-to-HRAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HRAS versus RRM1 in UCEC, with a Pearson correlation of 0.24.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HRAS→partner) and Y-score (partner→HRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRM1 →	+0.469	+0.849	.002	.009	3	7
LSCC	TXNDC5 →	-0.513	-0.572	<.001	<.001	3	4
LSCC	SPCS3 →	-0.540	-0.598	<.001	<.001	3	4
LSCC	STK4_S414 →	-0.684	-0.614	<.001	<.001	3	4
HNSC	PKP3 →	+0.726	+1.252	.001	<.001	3	4
HNSC	IPO7 →	+0.229	+0.817	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,913 associations by consensus.

HRAS vs RRM1 — UCEC

Explore this scatter interactively →