HRAS

Across TCGA patient cohorts, HRAS mutation is significantly associated with the RNA expression of many other genes, with 6,460 significant associations in total. THCA shows the largest number of these associations.

The most reproducible HRAS-associated genes across cancer lineages are LRRFIP2, FHOD3, and PARP8. Each is linked with HRAS in more than 4 cancer types. Because this analysis shows association rather than direction, both HRAS-to-partner and partner-to-HRAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRFIP2 grouped by HRAS-low versus HRAS-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HRAS→partner) and Y-score (partner→HRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRRFIP2 →	+0.520	+3.392	<.001	<.001	3	5
HNSC	FHOD3 →	+0.885	+2.932	<.001	<.001	3	4
HNSC	PARP8 →	+0.565	+3.482	<.001	.002	3	4
THCA	ACOT11 →	+0.593	+4.028	<.001	<.001	3	4
THCA	LMNTD2 →	+0.479	+3.339	.006	.005	3	4
THYM	PWRN4 →	+0.356	+3.485	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,460 associations by consensus.

LRRFIP2 by HRAS expression — HNSC

Explore this box plot interactively →