HPYR1

Across TCGA pan-cancer cohorts, HPYR1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HPYR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HPYR1 RNA is repressed in tumor relative to normal tissue. In most cancer types HPYR1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where HPYR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPYR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.207	<.001	10	view →
KICH	Female	All	−0.205	<.001	8	view →
BRCA	All	II,III,IV	+0.158	<.001	8	view →
LUSC	All	All	−0.031	.028	2	view →
READ	All	II,III,IV	+0.117	.042	1	view →
LUAD	Female	II,III,IV	−0.036	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HPYR1–KIRC

Open the KIRC breakdown →