HPX

Across TCGA pan-cancer cohorts, HPX mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HPX data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HPX mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HPX expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

COAD, LUAD, and GBM are the cancer types where HPX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.875	1.000	.016	24	view →
LUAD	DFS	Quartile	III,IV	0.171	0.847	.006	19	view →
GBM	DFS	Median	All	0.508	0.251	.006	14	view →
UCEC	OS	Median	II,III,IV	0.647	1.000	.017	12	view →
CCRCC	DFS	Quartile	III,IV	0.888	0.524	.013	8	view →
HNSC	OS	Median	All	0.957	1.000	.017	6	view →
LSCC	DFS	Median	II,III,IV	0.836	1.000	.005	5	view →
PDAC	DFS	Quartile	II,III,IV	0.542	0.245	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HPX–COAD (DFS)

Open the COAD breakdown →