HPX

Across TCGA patient cohorts, HPX RNA expression is significantly associated with the protein abundance of many other proteins, with 10,777 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HPX-associated proteins across cancer lineages are PLCG2, SLC16A1_S467, and SSC5D. Each is linked with HPX in more than 3 cancer types. Because this analysis shows association rather than direction, both HPX-to-partner and partner-to-HPX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPX versus PLCG2 in BRCA, with a Pearson correlation of -0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPX→partner) and Y-score (partner→HPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLCG2 →	-0.605	-1.271	<.001	<.001	3	4
BRCA	SLC16A1_S467 →	-0.920	-1.249	<.001	.001	3	3
BRCA	SSC5D →	+0.852	+1.572	<.001	<.001	3	3
CCRCC	PRELP →	+0.910	+0.366	<.001	.002	3	3
BRCA	ARL3 →	+0.405	+1.235	<.001	<.001	3	3
BRCA	ZNF280C →	-0.335	-1.121	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,777 associations by consensus.

HPX vs PLCG2 — BRCA

Explore this scatter interactively →