HPX

Across TCGA patient cohorts, HPX mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPX-associated genes across cancer lineages are ASNS, C-Raf, and 14-3-3_beta. Each is linked with HPX in more than 1 cancer types. Because this analysis shows association rather than direction, both HPX-to-partner and partner-to-HPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by HPX-low versus HPX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPX→partner) and Y-score (partner→HPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.416	+1.807	.001	.025	3	2
UCEC	C-Raf →	+0.110	+1.906	.033	.015	3	2
UCEC	14-3-3_beta →	-0.114	-2.673	.001	.005	3	1
UCEC	eEF2 →	+0.317	+2.321	.013	.033	3	1
UCEC	EGFR_pY1068 →	-0.248	-2.321	.006	.001	3	1
UCEC	eIF4E →	+0.220	+3.459	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by HPX expression — UCEC

Explore this box plot interactively →