HPX

Across TCGA cell cohorts, HPX RNA expression is significantly associated with the go_rna of many other GO terms, with 3,977 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible HPX-associated GO terms across cancer lineages are Macroautophagy, Cilium movement involved in cell motility, and Cilium or flagellum-dependent cell motility. Each is linked with HPX in more than 12 cancer types. Because this analysis shows association rather than direction, both HPX-to-partner and partner-to-HPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by HPX-low versus HPX-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPX→partner) and Y-score (partner→HPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Macroautophagy →	+0.048	+0.388	<.001	<.001	3	13
OESOPHAGUS	Cilium movement involved in cell motility →	-0.090	-0.417	.003	.006	3	13
BONE	Cilium or flagellum-dependent cell motility →	-0.096	-0.876	<.001	.002	3	12
BONE	Flagellated sperm motility →	-0.100	-0.896	<.001	.001	3	12
BONE	Cilium-dependent cell motility →	-0.096	-0.876	<.001	.002	3	12
BONE	Sperm motility →	-0.100	-0.896	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,977 associations by consensus.

Macroautophagy by HPX expression — OVARY

Explore this box plot interactively →