HPX

Across TCGA cell cohorts, HPX mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HPX-associated genes across cancer lineages are HSFY2, BPIFA1, and EBLN1. Each is linked with HPX in more than 1 cancer types. Because this analysis shows association rather than direction, both HPX-to-partner and partner-to-HPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by HPX-low versus HPX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPX→partner) and Y-score (partner→HPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSFY2 →	+0.009	+3.240	<.001	.004	3	1
LARGE_INTESTINE	BPIFA1 →	+0.145	+2.688	<.001	.008	3	1
LARGE_INTESTINE	EBLN1 →	+0.064	+3.104	.004	.008	3	1
LARGE_INTESTINE	CD300H →	+0.027	+3.678	<.001	.001	3	1
BLOOD_Leukemia	MMP27 →	+0.015	+4.384	<.001	.006	3	1
BLOOD_Leukemia	NXPH2 →	+0.023	+3.874	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

HSFY2 by HPX expression — LARGE_INTESTINE

Explore this box plot interactively →