HPSE

Across TCGA pan-cancer cohorts, HPSE mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HPSE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HPSE mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HPSE is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and CCRCC are the cancer types where HPSE tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPSE mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.200	.024	6	view →
LUAD	Male	II,III,IV	−0.364	<.001	4	view →
CCRCC	Male	All	+0.301	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HPSE–HNSC

Open the HNSC breakdown →