HPS6

Across TCGA patient cohorts, HPS6 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,559 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HPS6-associated proteins across cancer lineages are SLK, PLEKHA1, and VPS26A. Each is linked with HPS6 in more than 7 cancer types. Because this analysis shows association rather than direction, both HPS6-to-partner and partner-to-HPS6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS6 versus SLK in OV, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS6→partner) and Y-score (partner→HPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLK →	+0.296	+0.424	<.001	.001	3	8
LSCC	PLEKHA1 →	+0.378	+0.315	<.001	<.001	3	5
PDAC	VPS26A →	+0.204	+0.267	<.001	<.001	3	5
GBM	NHLRC2 →	+0.250	+0.370	<.001	<.001	3	5
OV	WAPL →	+0.261	+0.593	<.001	<.001	3	4
CCRCC	P4HB →	-0.451	-0.241	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,559 associations by consensus.

HPS6 vs SLK — OV

Explore this scatter interactively →