HPS6

Across TCGA patient cohorts, HPS6 protein abundance is significantly associated with the RNA expression of many other genes, with 9,424 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPS6-associated genes across cancer lineages are YY1, EMC1, and FGD2. Each is linked with HPS6 in more than 4 cancer types. Because this analysis shows association rather than direction, both HPS6-to-partner and partner-to-HPS6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS6 versus YY1 in LUAD, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS6→partner) and Y-score (partner→HPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	YY1 →	-0.358	-0.139	.001	.001	3	5
BRCA	EMC1 →	-0.459	-0.149	<.001	<.001	3	4
LSCC	FGD2 →	+0.743	+0.209	<.001	<.001	3	4
BRCA	WDR35 →	-0.471	-0.120	.004	.005	3	4
GBM	TARDBP →	-0.285	-0.206	<.001	<.001	3	4
LSCC	TTC5 →	-0.350	-0.128	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,424 associations by consensus.

HPS6 vs YY1 — LUAD

Explore this scatter interactively →