HPS6

Across TCGA patient cohorts, HPS6 mutation is significantly associated with the RNA expression of many other genes, with 1,927 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPS6-associated genes across cancer lineages are FGF7P1, MIR1238, and RNU6-1318P. Each is linked with HPS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS6-to-partner and partner-to-HPS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF7P1 grouped by HPS6-low versus HPS6-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS6→partner) and Y-score (partner→HPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	FGF7P1 →	+0.250	+5.679	<.001	.003	3	2
COAD	MIR1238 →	+0.675	+5.721	<.001	.001	3	2
UCEC	RNU6-1318P →	+0.322	+2.996	<.001	<.001	3	2
UCEC	TRAJ1 →	+0.470	+2.110	<.001	<.001	3	2
UCEC	BOLA3P3 →	+0.290	+2.033	.001	.001	3	2
UCEC	RNA5SP451 →	+0.217	+2.852	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,927 associations by consensus.

FGF7P1 by HPS6 expression — LGG

Explore this box plot interactively →