HPS6

Across TCGA patient cohorts, HPS6 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPS6-associated genes across cancer lineages are Di-Ras3, 14-3-3_beta, and EGFR_pY1068. Each is linked with HPS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS6-to-partner and partner-to-HPS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by HPS6-low versus HPS6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS6→partner) and Y-score (partner→HPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.152	-3.687	.006	.001	3	2
UCEC	14-3-3_beta →	-0.097	-1.847	.010	.049	3	1
UCEC	EGFR_pY1068 →	-0.196	-1.807	.037	.025	3	1
UCEC	eIF4E →	+0.201	+3.700	.011	.001	3	1
UCEC	IGFBP2 →	-0.852	-3.700	<.001	.001	3	1
UCEC	JNK2 →	+0.191	+1.415	.010	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Di-Ras3 by HPS6 expression — UCEC

Explore this box plot interactively →