HPS6

Across TCGA cell cohorts, HPS6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,016 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HPS6-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Melanosome assembly, and Negative regulation of interleukin-4 production. Each is linked with HPS6 in more than 15 cancer types. Because this analysis shows association rather than direction, both HPS6-to-partner and partner-to-HPS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by HPS6-low versus HPS6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS6→partner) and Y-score (partner→HPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Viral translational termination-reinitiation →	+0.099	+0.642	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	Melanosome assembly →	+0.100	+0.686	.006	<.001	3	10
BONE	Negative regulation of interleukin-4 production →	-0.453	-0.548	.004	<.001	3	10
URINARY_TRACT	Ornithine metabolic process →	+0.141	+0.513	.001	.008	3	10
BREAST	Protein lipoylation →	-0.116	-0.655	<.001	<.001	3	10
BREAST	Base-excision repair, gap-filling →	+0.144	+0.609	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,016 associations by consensus.

Viral translational termination-reinitiation by HPS6 expression — OESOPHAGUS

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