HPS6

Across TCGA cell cohorts, HPS6 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HPS6-associated genes across cancer lineages are SLC32A1, HAND1, and PLPPR4. Each is linked with HPS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS6-to-partner and partner-to-HPS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by HPS6-low versus HPS6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS6→partner) and Y-score (partner→HPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.578	+4.034	<.001	.001	3	1
BLOOD_Leukemia	HAND1 →	+0.020	+3.408	<.001	.005	3	1
BLOOD_Leukemia	PLPPR4 →	+0.147	+3.474	<.001	.007	3	1
BLOOD_Leukemia	LRIT1 →	+0.023	+3.269	<.001	.007	3	1
BLOOD_Leukemia	CD1B →	+2.901	+3.560	.001	.005	3	1
BLOOD_Leukemia	FRZB →	+0.445	+3.626	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

SLC32A1 by HPS6 expression — BLOOD_Leukemia

Explore this box plot interactively →