HPS5

Across TCGA pan-cancer cohorts, HPS5 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HPS5 data layer compared with 21 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HPS5 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HPS5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, BRCA, and LUSC are the cancer types where HPS5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.431	.004	32	view →
BRCA	OS	Median	II,III,IV	0.103	0.564	.016	12	view →
LUSC	DFS	Median	II,III,IV	0.079	0.750	<.001	12	view →
LUAD	DFS	Median	All	1.000	0.313	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HPS5–UCEC (DFS)

Open the UCEC breakdown →