HPS5

Across TCGA pan-cancer cohorts, HPS5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HPS5 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HPS5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HPS5 expression acts as an unfavorable survival marker.

CCRCC, PDAC, and COAD are the cancer types where HPS5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.224	0.812	<.001	45	view →
PDAC	DFS	Tertile	II,III,IV	0.626	0.937	.002	33	view →
COAD	DFS	Quartile	II,III,IV	0.727	1.000	.034	12	view →
LUAD	OS	Tertile	II,III,IV	0.902	1.000	.034	3	view →
GBM	DFS	Median	All	0.676	0.815	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HPS5–CCRCC (DFS)

Open the CCRCC breakdown →