HPS5

Across TCGA pan-cancer cohorts, HPS5 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HPS5’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where HPS5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HPS5 is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

CCRCC, HNSC, and PDAC are the cancer types where HPS5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPS5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+0.335	<.001	12	view →
HNSC	All	II,III,IV	+0.247	<.001	11	view →
PDAC	All	All	−0.215	.023	3	view →
LUAD	All	All	−0.078	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HPS5–CCRCC

Open the CCRCC breakdown →