HPS5

Across TCGA patient cohorts, HPS5 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,008 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPS5-associated proteins across cancer lineages are FERMT3, PPP1R18, and TBC1D2B. Each is linked with HPS5 in more than 5 cancer types. Because this analysis shows association rather than direction, both HPS5-to-partner and partner-to-HPS5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS5 versus FERMT3 in GBM, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS5→partner) and Y-score (partner→HPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FERMT3 →	+0.462	+0.232	<.001	<.001	3	6
COAD	PPP1R18 →	+0.438	+0.565	<.001	<.001	3	6
GBM	TBC1D2B →	+0.349	+0.313	<.001	<.001	3	6
OV	WIPF1 →	+0.364	+0.461	.002	.001	3	6
OV	DOCK11 →	+0.449	+0.521	.001	.001	3	5
OV	DOCK2 →	+0.492	+0.573	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,008 associations by consensus.

HPS5 vs FERMT3 — GBM

Explore this scatter interactively →