HPS5

Across TCGA patient cohorts, HPS5 protein abundance is significantly associated with the RNA expression of many other genes, with 15,543 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPS5-associated genes across cancer lineages are CD86, CCL4, and PLEK. Each is linked with HPS5 in more than 6 cancer types. Because this analysis shows association rather than direction, both HPS5-to-partner and partner-to-HPS5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS5 versus CD86 in HNSC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS5→partner) and Y-score (partner→HPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD86 →	+1.066	+0.265	<.001	<.001	3	7
COAD	CCL4 →	+1.613	+0.894	<.001	<.001	3	7
COAD	PLEK →	+1.955	+0.890	<.001	.001	3	7
CCRCC	CD72 →	+0.621	+0.172	<.001	<.001	3	6
HNSC	GPR65 →	+0.764	+0.254	<.001	<.001	3	6
GBM	LAIR1 →	+0.876	+0.300	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,543 associations by consensus.

HPS5 vs CD86 — HNSC

Explore this scatter interactively →