HPS5

Across TCGA patient cohorts, HPS5 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPS5-associated genes across cancer lineages are Cyclin-B1, Notch1, and Rab25. Each is linked with HPS5 in more than 2 cancer types. Because this analysis shows association rather than direction, both HPS5-to-partner and partner-to-HPS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by HPS5-low versus HPS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS5→partner) and Y-score (partner→HPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.732	+2.392	<.001	<.001	3	3
UCEC	Notch1 →	+0.206	+2.424	<.001	.001	3	2
UCEC	Rab25 →	-0.290	-2.000	.013	.029	3	2
UCEC	Src_pY527 →	-0.326	-1.690	.032	.042	3	2
UCEC	STAT5a →	+0.407	+2.222	.003	.010	3	2
UCEC	ASNS →	+0.407	+1.700	.001	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Cyclin-B1 by HPS5 expression — UCEC

Explore this box plot interactively →