HPS5

Across TCGA cell cohorts, HPS5 mutation is significantly associated with the RNA expression of many other genes, with 525 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HPS5-associated genes across cancer lineages are MS4A13, C10orf99, and IGFL3. Each is linked with HPS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS5-to-partner and partner-to-HPS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A13 grouped by HPS5-low versus HPS5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS5→partner) and Y-score (partner→HPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MS4A13 →	+0.028	+4.058	<.001	.007	3	2
LUNG_SCLC	C10orf99 →	+0.066	+4.938	<.001	<.001	3	1
LUNG_SCLC	IGFL3 →	+0.223	+3.523	<.001	.008	3	1
LUNG_SCLC	C5orf67 →	+0.197	+4.070	<.001	.003	3	1
LUNG_SCLC	PRR33 →	+0.028	+3.898	.008	.005	3	1
LUNG_NSCLC_LUAD	PRAMEF14 →	+0.009	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 525 associations by consensus.

MS4A13 by HPS5 expression — LUNG_SCLC

Explore this box plot interactively →