HPS3

Across TCGA pan-cancer cohorts, HPS3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HPS3 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HPS3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HPS3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where HPS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.808	0.982	.001	51	view →
UCEC	DFS	Tertile	All	0.740	0.952	.005	32	view →
PDAC	OS	Median	All	0.811	0.876	.002	21	view →
LUAD	DFS	Tertile	II,III,IV	0.897	0.393	.003	19	view →
GBM	OS	Tertile	All	0.417	0.618	.031	5	view →
LSCC	OS	Median	II,III,IV	0.716	1.000	.033	3	view →
HNSC	DFS	Quartile	III,IV	0.475	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HPS3–CCRCC (OS)

Open the CCRCC breakdown →