HPS3

Across TCGA pan-cancer cohorts, HPS3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HPS3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HPS3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HPS3 is over-expressed in tumor.

HNSC, CCRCC, and LSCC are the cancer types where HPS3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPS3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.415	<.001	12	view →
CCRCC	All	IV	+0.414	<.001	11	view →
LSCC	All	All	+0.083	<.001	7	view →
PDAC	All	All	+0.179	.002	4	view →
LUAD	All	II,III,IV	+0.081	.011	3	view →
COAD	Female	III,IV	+0.365	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HPS3–HNSC

Open the HNSC breakdown →