HPS3

Across TCGA patient cohorts, HPS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,613 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HPS3-associated proteins across cancer lineages are FXR1, GMPS, and U2SURP. Each is linked with HPS3 in more than 6 cancer types. Because this analysis shows association rather than direction, both HPS3-to-partner and partner-to-HPS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS3 versus FXR1 in LSCC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS3→partner) and Y-score (partner→HPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FXR1 →	+0.392	+0.605	<.001	<.001	3	7
LSCC	GMPS →	+0.585	+0.622	<.001	<.001	3	6
HNSC	U2SURP →	+0.206	+0.873	<.001	.001	3	5
LSCC	UBXN7 →	+0.457	+0.656	<.001	<.001	3	5
LSCC	BBX_S844 →	+0.335	+0.441	.002	.004	3	5
UCEC	CHERP →	+0.208	+0.418	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,613 associations by consensus.

HPS3 vs FXR1 — LSCC

Explore this scatter interactively →