HPS3

Across TCGA patient cohorts, HPS3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,825 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPS3-associated genes across cancer lineages are CLEC6A, APOC1, and IL12RB1. Each is linked with HPS3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HPS3-to-partner and partner-to-HPS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS3 versus CLEC6A in HNSC, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS3→partner) and Y-score (partner→HPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLEC6A →	+0.564	+0.194	.002	.001	3	5
HNSC	APOC1 →	+1.284	+0.213	<.001	.001	3	5
HNSC	IL12RB1 →	+0.843	+0.172	<.001	<.001	3	5
GBM	HCK →	+0.937	+0.277	<.001	<.001	3	4
HNSC	TFEC →	+0.823	+0.215	<.001	<.001	3	4
GBM	SLC15A3 →	+0.818	+0.329	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,825 associations by consensus.

HPS3 vs CLEC6A — HNSC

Explore this scatter interactively →