HPS3

Across TCGA patient cohorts, HPS3 protein abundance is significantly associated with the protein abundance of many other proteins, with 17,526 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPS3-associated proteins across cancer lineages are HPS6, HPS5, and HPS5_S563. Each is linked with HPS3 in more than 7 cancer types. Because this analysis shows association rather than direction, both HPS3-to-partner and partner-to-HPS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS3 versus HPS6 in GBM, with a Pearson correlation of 0.60.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS3→partner) and Y-score (partner→HPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HPS6 →	+0.227	+0.251	<.001	<.001	3	8
GBM	HPS5 →	+0.332	+0.295	<.001	<.001	3	7
LSCC	HPS5_S563 →	+0.469	+0.189	<.001	<.001	3	6
LUAD	HPS5_S695 →	+0.424	+0.161	<.001	<.001	3	6
GBM	CXorf38 →	+0.304	+0.284	<.001	<.001	2	6
HNSC	RNF213 →	+0.447	+0.198	<.001	.002	1	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,526 associations by consensus.

HPS3 vs HPS6 — GBM

Explore this scatter interactively →