HPS3

Across TCGA patient cohorts, HPS3 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPS3-associated genes across cancer lineages are p90 RSK, IGFBP2, and PRDX1. Each is linked with HPS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HPS3-to-partner and partner-to-HPS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by HPS3-low versus HPS3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS3→partner) and Y-score (partner→HPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	p90 RSK →	+0.208	+2.832	.033	.034	3	3
BLCA	IGFBP2 →	-0.357	-2.459	.034	.020	3	2
BLCA	PRDX1 →	+0.248	+2.459	.013	.020	3	2
UCEC	EGFR_pY1068 →	-0.173	-1.169	.016	.017	3	2
UCEC	eIF4E →	+0.132	+1.536	.029	.002	3	2
UCEC	FoxM1 →	+0.158	+1.169	.033	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

p90 RSK by HPS3 expression — BLCA

Explore this box plot interactively →