HPS3

Across TCGA cell cohorts, HPS3 mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HPS3-associated genes across cancer lineages are ZNF454, OR10K1, and RNASE3. Each is linked with HPS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPS3-to-partner and partner-to-HPS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF454 grouped by HPS3-low versus HPS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS3→partner) and Y-score (partner→HPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF454 →	+0.151	+2.144	.007	.008	3	2
BLOOD_Leukemia	OR10K1 →	+0.483	+4.234	<.001	.003	3	2
URINARY_TRACT	RNASE3 →	+0.032	+4.087	<.001	.009	3	1
URINARY_TRACT	FAM71C →	+0.010	+4.087	<.001	.009	3	1
URINARY_TRACT	OR52N4 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	OR10G4 →	+0.012	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

ZNF454 by HPS3 expression — LARGE_INTESTINE

Explore this box plot interactively →