HPS3

Across TCGA cell cohorts, HPS3 mutation is significantly associated with the mutation status of many other genes, with 2,878 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HPS3-associated genes across cancer lineages are IRF2BPL, TTLL4, and ACAP1. Each is linked with HPS3 in more than 4 cancer types. Because this analysis shows association rather than direction, both HPS3-to-partner and partner-to-HPS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRF2BPL grouped by HPS3-low versus HPS3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS3→partner) and Y-score (partner→HPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IRF2BPL →	+3.847	+5.108	.001	.001	1	5
BLOOD_Leukemia	TTLL4 →	+4.050	+3.870	.002	.002	1	4
OVARY	ACAP1 →	+4.415	+4.977	.007	.007	1	4
LARGE_INTESTINE	GPR158 →	+1.956	+2.501	.002	.002	1	4
BLOOD_Lymphoma	RALGDS →	+3.584	+4.922	.001	.001	1	4
BLOOD_Lymphoma	DNMT3A →	+5.584	+5.014	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,878 associations by consensus.

IRF2BPL by HPS3 expression — BLOOD_Lymphoma

Explore this box plot interactively →