HPS1

Across TCGA patient cohorts, HPS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,534 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPS1-associated proteins across cancer lineages are VPS35, IDE, and VPS26A. Each is linked with HPS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HPS1-to-partner and partner-to-HPS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPS1 versus VPS35 in PDAC, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS1→partner) and Y-score (partner→HPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VPS35 →	+0.155	+0.246	.001	.002	2	5
LSCC	IDE →	+0.266	+0.417	<.001	<.001	3	4
GBM	VPS26A →	+0.247	+0.653	<.001	<.001	3	4
PDAC	VPS29 →	+0.346	+0.278	<.001	<.001	3	4
UCEC	STT3A →	-0.509	-0.741	<.001	.001	3	3
PDAC	C8orf33 →	-0.351	-0.204	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,534 associations by consensus.

HPS1 vs VPS35 — PDAC

Explore this scatter interactively →