HPS1

Across TCGA cell cohorts, HPS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,570 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HPS1-associated GO terms across cancer lineages are Protein localization to endosome, Canonical NF-kappaB signal transduction, and Melanosome organization. Each is linked with HPS1 in more than 10 cancer types. Because this analysis shows association rather than direction, both HPS1-to-partner and partner-to-HPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to endosome grouped by HPS1-low versus HPS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPS1→partner) and Y-score (partner→HPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein localization to endosome →	+0.197	+0.884	<.001	<.001	3	11
BONE	Canonical NF-kappaB signal transduction →	+0.071	+0.697	<.001	<.001	3	10
SKIN	Melanosome organization →	+0.086	+0.667	<.001	<.001	3	9
SKIN	Pigment granule organization →	+0.086	+0.667	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.052	+0.686	<.001	<.001	3	9
BONE	Retrograde transport, endosome to Golgi →	+0.061	+0.834	.003	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,570 associations by consensus.

Protein localization to endosome by HPS1 expression — BONE

Explore this box plot interactively →