HPR

Across TCGA pan-cancer cohorts, HPR mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HPR data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HPR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HPR expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

LUAD, LSCC, and UCEC are the cancer types where HPR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.333	0.819	.003	18	view →
LSCC	DFS	Tertile	All	0.836	1.000	.002	15	view →
UCEC	DFS	Tertile	All	0.821	0.982	.016	14	view →
COAD	DFS	Median	III,IV	0.835	1.000	.033	6	view →
GBM	OS	Median	All	0.877	0.658	.017	5	view →
HNSC	DFS	Median	IV	0.910	0.697	.018	5	view →
PDAC	DFS	Tertile	All	0.851	0.771	.016	3	view →
CCRCC	OS	Median	III,IV	0.595	0.786	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HPR–LUAD (OS)

Open the LUAD breakdown →