HPR

Across TCGA patient cohorts, HPR mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPR-associated genes across cancer lineages are A-Raf_pS299, GATA6, and ACVRL1. Each is linked with HPR in more than 1 cancer types. Because this analysis shows association rather than direction, both HPR-to-partner and partner-to-HPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by HPR-low versus HPR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPR→partner) and Y-score (partner→HPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.133	-2.999	.010	.035	3	1
UCEC	GATA6 →	-0.150	-2.108	.026	.018	3	1
UCEC	ACVRL1 →	-0.223	-3.787	<.001	<.001	3	1
UCEC	Notch1 →	+0.161	+2.179	.008	.034	3	1
UCEC	Paxillin →	+0.305	+2.594	.007	.006	3	1
UCEC	AMPK_alpha →	-0.190	-2.115	.022	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

A-Raf_pS299 by HPR expression — UCEC

Explore this box plot interactively →