HPR

Across TCGA cell cohorts, HPR RNA expression is significantly associated with the go_rna of many other GO terms, with 832 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HPR-associated GO terms across cancer lineages are Protein localization to phagophore assembly site, Resolution of mitotic recombination intermediates, and Regulation of skeletal muscle satellite cell proliferation. Each is linked with HPR in more than 3 cancer types. Because this analysis shows association rather than direction, both HPR-to-partner and partner-to-HPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to phagophore assembly site grouped by HPR-low versus HPR-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPR→partner) and Y-score (partner→HPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Protein localization to phagophore assembly site →	+0.045	+0.021	.006	.007	3	4
BREAST	Resolution of mitotic recombination intermediates →	+0.091	+0.047	.001	.003	3	3
LUNG_NSCLC_LUSC	Regulation of skeletal muscle satellite cell proliferation →	+0.170	+0.067	<.001	.006	3	3
LUNG_NSCLC_LUSC	Regulation of skeletal muscle cell proliferation →	+0.170	+0.067	<.001	.006	3	3
BLOOD_Lymphoma	Macroautophagy →	+0.025	+0.029	.002	.005	3	3
BLOOD_Lymphoma	Protein localization to basolateral plasma membrane →	-0.073	-0.027	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 832 associations by consensus.

Protein localization to phagophore assembly site by HPR expression — BLOOD_Lymphoma

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