HPN

Across TCGA patient cohorts, HPN RNA expression is significantly associated with the protein abundance of many other proteins, with 19,711 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HPN-associated proteins across cancer lineages are DDAH1, FN3K, and LRBA. Each is linked with HPN in more than 4 cancer types. Because this analysis shows association rather than direction, both HPN-to-partner and partner-to-HPN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPN versus DDAH1 in BRCA, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPN→partner) and Y-score (partner→HPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDAH1 →	+0.808	+1.959	<.001	<.001	3	5
HNSC	FN3K →	+0.755	+1.259	<.001	<.001	3	5
LSCC	LRBA →	+0.352	+1.180	<.001	<.001	3	5
GBM	LRP2 →	+0.884	+1.438	.002	.002	3	5
GBM	MAP2K4 →	+0.477	+0.493	<.001	<.001	3	5
PDAC	PGPEP1 →	+0.375	+1.006	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,711 associations by consensus.

HPN vs DDAH1 — BRCA

Explore this scatter interactively →