HPN

Across TCGA patient cohorts, HPN protein abundance is significantly associated with the RNA expression of many other genes, with 2,599 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HPN-associated genes across cancer lineages are ENAM, LRRC19, and HPN-AS1. Each is linked with HPN in more than 1 cancer types. Because this analysis shows association rather than direction, both HPN-to-partner and partner-to-HPN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPN versus ENAM in CCRCC, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPN→partner) and Y-score (partner→HPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ENAM →	+0.817	+0.308	<.001	.004	3	2
UCEC	LRRC19 →	+1.058	+0.938	.002	.005	3	2
UCEC	HPN-AS1 →	+1.221	+1.093	<.001	<.001	3	2
UCEC	KRT8P33 →	-1.506	-1.216	<.001	.002	3	2
LUAD	FDX1 →	+0.474	+0.505	.001	.001	3	2
CCRCC	LTBP3 →	-0.656	-0.422	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,599 associations by consensus.

HPN vs ENAM — CCRCC

Explore this scatter interactively →