HPN

Across TCGA patient cohorts, HPN mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPN-associated genes across cancer lineages are p90 RSK, p27_pT198, and eIF4E. Each is linked with HPN in more than 1 cancer types. Because this analysis shows association rather than direction, both HPN-to-partner and partner-to-HPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by HPN-low versus HPN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPN→partner) and Y-score (partner→HPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.162	+2.009	.018	.017	3	2
SKCM	p27_pT198 →	+0.126	+2.824	.043	.034	3	2
UCEC	eIF4E →	+0.167	+2.000	.027	.030	3	1
UCEC	ERK2 →	+0.143	+3.459	.038	.005	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.369	+2.115	.016	.016	3	1
UCEC	JNK2 →	+0.247	+1.901	<.001	.028	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p90 RSK by HPN expression — UCEC

Explore this box plot interactively →