HPN

Across TCGA cell cohorts, HPN RNA expression is significantly associated with the go_rna of many other GO terms, with 2,490 significant associations in total. LIVER shows the largest number of these associations.

The most reproducible HPN-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Post-translational protein targeting to endoplasmic reticulum membrane. Each is linked with HPN in more than 7 cancer types. Because this analysis shows association rather than direction, both HPN-to-partner and partner-to-HPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by HPN-low versus HPN-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPN→partner) and Y-score (partner→HPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of myoblast fusion →	+0.097	+1.756	.002	.002	3	8
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.089	+1.756	.003	.002	3	8
OVARY	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.072	+1.754	<.001	<.001	3	8
BREAST	ATP synthesis coupled electron transport →	+0.067	+1.394	.003	.005	3	7
BREAST	Mitochondrial ATP synthesis coupled electron transport →	+0.067	+1.394	.003	.005	3	7
BREAST	Golgi to plasma membrane transport →	+0.070	+1.704	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,490 associations by consensus.

Negative regulation of myoblast fusion by HPN expression — OVARY

Explore this box plot interactively →