HPN

Across TCGA cell cohorts, HPN mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HPN-associated genes across cancer lineages are CBY1, PDE4C, and MAP3K8. Each is linked with HPN in more than 1 cancer types. Because this analysis shows association rather than direction, both HPN-to-partner and partner-to-HPN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBY1 grouped by HPN-low versus HPN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPN→partner) and Y-score (partner→HPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.580	+3.137	.003	.007	3	1
LARGE_INTESTINE	PDE4C →	+0.704	+3.321	<.001	.004	3	1
LARGE_INTESTINE	MAP3K8 →	-1.071	-3.278	<.001	.006	3	1
LARGE_INTESTINE	IQCG →	+1.173	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TAS2R4 →	+0.527	+3.247	<.001	.004	3	1
LARGE_INTESTINE	ACSBG2 →	+0.196	+3.381	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

CBY1 by HPN expression — LARGE_INTESTINE

Explore this box plot interactively →