Across TCGA pan-cancer cohorts, HPN-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HPN-AS1 data layer.

The strongest signal is observed in thymoma (THYM), where higher HPN-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HPN-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and SKCM show a favorable association.

THYM, KIRP, and LGG are the cancer types where HPN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Tertile	All	0.694	1.000	<.001	59	view →
KIRP	DFS	Median	III,IV	0.860	0.173	<.001	49	view →
LGG	OS	Tertile	All	0.831	0.938	<.001	37	view →
ACC	DFS	Tertile	All	0.137	0.771	<.001	36	view →
CHOL	DFS	Tertile	II,III,IV	0.103	0.731	.002	33	view →
COAD	DFS	Quartile	All	0.665	0.818	.003	29	view →
SKCM	OS	Median	All	0.395	0.252	<.001	22	view →
LIHC	OS	Quartile	All	0.767	0.606	.010	20	view →
LUSC	DFS	Median	II,III,IV	0.925	0.549	<.001	19	view →
MESO	DFS	Median	IV	0.467	0.184	.010	18	view →
PRAD	DFS	Median	All	0.842	0.920	.005	16	view →
STAD	OS	Median	III,IV	0.609	0.365	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

Exploration

Same gene, other analysis: HPN-AS1 tumor-vs-normal RNA expression · all HPN-AS1 data types