HPGDS

Across TCGA pan-cancer cohorts, HPGDS Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HPGDS data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher HPGDS Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HPGDS expression acts as an unfavorable survival marker.

BLCA, CESC, and READ are the cancer types where HPGDS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.158	0.720	<.001	45	view →
CESC	OS	Median	All	0.145	0.801	<.001	24	view →
READ	OS	Median	All	0.183	0.828	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SCLC	OS	Median	II,III,IV	0.152	0.777	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HPGDS–BLCA (OS)

Open the BLCA breakdown →