HPGDS

Across TCGA pan-cancer cohorts, HPGDS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HPGDS data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher HPGDS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HPGDS expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and COAD are the cancer types where HPGDS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.942	0.495	.001	41	view →
LUAD	DFS	Quartile	All	0.833	0.432	.003	13	view →
COAD	DFS	Tertile	II,III,IV	0.812	1.000	.029	12	view →
GBM	DFS	Tertile	All	0.788	0.641	.036	3	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HPGDS–PDAC (DFS)

Open the PDAC breakdown →