HPGDS

Across TCGA pan-cancer cohorts, HPGDS mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HPGDS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HPGDS mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HPGDS is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and COAD are the cancer types where HPGDS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HPGDS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−1.228	<.001	11	view →
LSCC	Male	All	−1.484	<.001	9	view →
COAD	Female	III,IV	−1.348	<.001	9	view →
LUAD	Male	III,IV	−0.787	<.001	9	view →
PDAC	Female	All	+0.826	<.001	7	view →
CCRCC	Male	III,IV	−0.596	<.001	6	view →
OV	All	All	−1.003	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HPGDS–HNSC

Open the HNSC breakdown →