HPGDS

Across TCGA patient cohorts, HPGDS mutation is significantly associated with the RNA expression of many other genes, with 442 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPGDS-associated genes across cancer lineages are RN7SL478P, MIR1263, and MIR1283-1. Each is linked with HPGDS in more than 1 cancer types. Because this analysis shows association rather than direction, both HPGDS-to-partner and partner-to-HPGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL478P grouped by HPGDS-low versus HPGDS-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPGDS→partner) and Y-score (partner→HPGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL478P →	+0.226	+4.975	<.001	.002	3	1
COAD	MIR1263 →	+1.494	+7.741	<.001	.009	3	1
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	1
COAD	MIR1179 →	+1.171	+7.741	<.001	.009	3	1
COAD	MTATP6P30 →	+0.147	+7.741	<.001	.009	3	1
UCEC	LAMTOR1 →	+0.431	+3.470	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 442 associations by consensus.

RN7SL478P by HPGDS expression — BRCA

Explore this box plot interactively →