HPGDS

Across TCGA patient cohorts, HPGDS mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPGDS-associated genes across cancer lineages are ATM, GSK-3a-b_pS21_S9, and JNK_pT183_Y185. Each is linked with HPGDS in more than 1 cancer types. Because this analysis shows association rather than direction, both HPGDS-to-partner and partner-to-HPGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HPGDS-low versus HPGDS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPGDS→partner) and Y-score (partner→HPGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.911	-3.169	<.001	.020	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.568	+3.009	.015	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.221	-3.156	.016	.020	3	1
UCEC	MEK1 →	+0.613	+3.169	.002	.020	3	1
UCEC	Notch1 →	+0.198	+2.820	.010	.035	3	1
UCEC	Tuberin_pT1462 →	+0.411	+3.009	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ATM by HPGDS expression — UCEC

Explore this box plot interactively →