HPGDS

Across TCGA cell cohorts, HPGDS RNA expression is significantly associated with the go_rna of many other GO terms, with 1,778 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HPGDS-associated GO terms across cancer lineages are Positive regulation of protein localization to mitochondrion, Negative regulation of CD4-positive, alpha-beta T cell differentiation, and rRNA transcription. Each is linked with HPGDS in more than 4 cancer types. Because this analysis shows association rather than direction, both HPGDS-to-partner and partner-to-HPGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to mitochondrion grouped by HPGDS-low versus HPGDS-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HPGDS→partner) and Y-score (partner→HPGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of protein localization to mitochondrion →	+0.081	+2.411	<.001	<.001	3	5
CNS	Negative regulation of CD4-positive, alpha-beta T cell differentiation →	-0.133	-0.032	<.001	.003	3	4
BLOOD_Myeloma	rRNA transcription →	+0.079	+0.028	.002	.006	3	4
BLOOD_Leukemia	Cellular response to arsenic-containing substance →	+0.083	+1.684	<.001	.001	3	4
BLOOD_Leukemia	snRNA metabolic process →	+0.035	+1.683	.001	.006	3	4
BLOOD_Leukemia	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.072	+2.656	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,778 associations by consensus.

Positive regulation of protein localization to mitochondrion by HPGDS expression — BLOOD_Leukemia

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