HPF1

Across TCGA patient cohorts, HPF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,611 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HPF1-associated proteins across cancer lineages are GAPT_S74, SET_S7, and OTUD4. Each is linked with HPF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HPF1-to-partner and partner-to-HPF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HPF1 versus GAPT_S74 in UCEC, with a Pearson correlation of -0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HPF1→partner) and Y-score (partner→HPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPT_S74 →	-0.984	-0.878	.002	.001	3	5
GBM	SET_S7 →	-0.407	-0.319	.005	.007	3	4
COAD	OTUD4 →	+0.333	+0.656	<.001	<.001	3	4
PDAC	P4HA2 →	+0.621	+0.410	<.001	<.001	3	4
LSCC	NCAPG →	+0.437	+0.595	.003	<.001	3	4
BRCA	DNAJC19 →	-0.502	-0.441	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,611 associations by consensus.

HPF1 vs GAPT_S74 — UCEC

Explore this scatter interactively →