HPF1

Across TCGA patient cohorts, HPF1 mutation is significantly associated with the RNA expression of many other genes, with 639 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPF1-associated genes across cancer lineages are RNU6-1022P, TSPY19P, and MIR3619. Each is linked with HPF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPF1-to-partner and partner-to-HPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1022P grouped by HPF1-low versus HPF1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPF1→partner) and Y-score (partner→HPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1022P →	+0.458	+7.924	<.001	.008	3	2
LUSC	TSPY19P →	+0.119	+7.924	<.001	.008	3	2
SKCM	MIR3619 →	+0.852	+4.765	<.001	.003	3	2
UCEC	TCP11X3P →	+0.288	+2.087	<.001	.005	3	2
BLCA	RNU6-1167P →	+0.288	+7.640	<.001	.009	3	1
BLCA	RNA5SP428 →	+0.213	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 639 associations by consensus.

RNU6-1022P by HPF1 expression — LUSC

Explore this box plot interactively →