HPF1

Across TCGA patient cohorts, HPF1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HPF1-associated genes across cancer lineages are eIF4G, ER-alpha, and FOXO3a_pS318_S321. Each is linked with HPF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HPF1-to-partner and partner-to-HPF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by HPF1-low versus HPF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HPF1→partner) and Y-score (partner→HPF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.365	+2.999	.011	.035	3	1
UCEC	ER-alpha →	-0.755	-2.986	.048	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.127	-3.160	.028	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.156	-3.169	.047	.019	3	1
UCEC	JNK2 →	+0.244	+2.584	.008	.011	3	1
UCEC	Ku80 →	+0.261	+1.887	.017	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4G by HPF1 expression — UCEC

Explore this box plot interactively →